Natural and synthetic analogues of melatonin and related compounds I. Effects on the reproductive system of the male Syrian hamster
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 56 (2-3) , 187-197
- https://doi.org/10.1007/bf01243277
Abstract
The potential antigonadotrophic properties of a number of synthetic and natural melatonin analogues were examined. Adult male hamsters received daily subcutaneous injections (25μg/animal/day) each afternoon for 7 or 10 weeks. The only analogue to possess antigonadotrophic activity similar to melatonin was 6-chloromelatonin; melatonin and 6-chloromelatonin produced a significant reduction in both testicular and accessory sex organ weights, plasma LH and pituitary prolactin. These results suggest that, in the Syrian hamster, 6-chloromelatonin acts as a melatonin agonist and may be of use to elucidate further the physiological role of melatonin.Keywords
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