Steroid assays in saliva: A method to detect plasmatic contaminations

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Abstract
Plasmatic and salivary levels of six steroid hormones in adult males and females are given and compared to the data of the literature. These steroids are : cortisol (F), dehydroepian-drosterone (DHA) and its sulphate (DHAS), androstenedione (A), testosterone (T) and 11βOH androstenedione (OHA). The salivary assay of the last compound is an original. The correlations between salivary and plasmatic values are presented and confirm that this method is a reliable alternative for hormonal investigations. From these data and from those of the literature, the salivary versus plasmatic ratio are calculated. From the fact that high concentrations of DHAS in saliva generally stem from blood contamination, we derive a method to estimate the amount of this contamination and its impact on other steroids measured on the same saliva sample.