Influence of Sulfonamides and Para-aminobenzoic Acid on the Growth of Lupinus albus.

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Abstract
Pharmacological studies on root-growth of Lupinus albus seedlings under 1 standardized and rigidly controlled conditions reveal that: (1) Of the 3 amino-benzoic acids the meta isomer is the most toxic, and the para isomer is the least toxic. (2) Para-aminobenzoic acid exerts a diphasic effect on 1 root-growth: Very weak dilutions are growth: promoting, while stronger concentrations are growth-inhibitory. (3) Sulfanilamide also exhibits a similar action, some concentrations inhibiting growth while other concentrations promote it. (4) Similar findings were made with 6 other sulfonamides which were examined. (5) Combinations of sulfanilamide and para-aminobenzoic acid in every case exerted not an antagonistic, but on the contrary, a synergistic or potentiated depression on growth of Lupinus albus roots.