PREPARATION AND PROPERTIES OF ALEXINATED INTERMEDIATES THAT REACT WITH CONGLUTININ .I. GUINEA-PIG COMPLEMENT

  • 1 January 1966
    • journal article
    • research article
    • Vol. 11  (3) , 243-+
Abstract
Evidence has been advanced confirming earlier work that conglutinin reacts solely with a determinant exposed in fixed C[image]3a. The reactivity is not influenced by the decay of earlier components or the activity of later ones. Heterologous sources of C[image]3a (rabbit and human) reacting with guinea pig EAC[image]142 give conglutinable intermediates. The stability of EAC[image]1423a for conglutination is much greater than for lysis. The study of decayed intermediates which still react with conglutinin suggests that the bulk of the C[image]3a fixed has after some time no hemolytic function. Possible explanations of this phenomenon are discussed. The "long-term" func-tions of the bulk of the fixed C[image]3a may therefore be associated with manifestations of complement activities other than hemolysis.