Restriction Enzyme-based Method for Transforming Growth Factor-β1 Genotyping: Nonisotopic Detection of Polymorphisms in Codons 10 and 25 and the 5′-Flanking Region

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Abstract
Transforming growth factor-β1 (TGF-β1) modulates a wide spectrum of biological activities, including cell proliferation, differentiation, and adhesion as well as extracellular matrix formation. The involvement of TGF-β1 in inflammation and tissue repair has been established in the past few years, suggesting a crucial role for this cytokine in pathologies of the cardiovascular system, kidney (chronic allograft rejection in kidney transplantation, glomerulonephritis, and diabetic nephropathy), bones (osteoporosis), skin (systemic sclerosis), lung (idiopathic lung fibrosis and asthma), and liver (cirrhosis).