Treatment of neuroleptic-induced akathisia with the 5-HT2antagonist mianserin

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Abstract
Background: Serotonin (5-HT): dopamine imbalance may underlie neuroleptic-induced akathisia.Aim: To evaluate the efficacy of the 5-HT2antagonist, mianserin in neuroleptic-induced akathisia.Methods: Thirty neuroleptic-treated patients with schizophrenia were randomly allocated in a double-blind design to receive either mianserin (15 mg/day) or placebo for five days. Patients were assessed at baseline and on Days 3 and 5 by the Barnes Akathisia Scale (BARS), as well as by other relevant clinical rating scales.Results: Compared with the placebo group, the mianserin-treated patients showed a significant reduction in all four BARS subscales by Day 5, with mean reductions in the BARS global score of 9.9% and 52.2%, respectively (P=0.006). Response to treatment (a reduction of at least two points on the BARS global subscale), was noted in six patients (40%) in the mianserin group and only one patient (9.1%) in the placebo group (P=0.04, log odds ratio 2.23).Conclusions: Mianserin at a low dose may be a promising therapeutic option for patients with acute neuroleptic-induced akathisia.

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