Acute pulmonary edema and plasma kininogen consumption in the adrenaline-treated rat: Inhibition by acetylsalicylic acid and resistance to salicylate and indomethacin
- 1 January 1975
- journal article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 288 (2-3) , 319-321
- https://doi.org/10.1007/bf00500537
Abstract
Pulmonary edema and plasma kininogen consumption caused by intravenously administered adrenaline, were inhibited in rats pretreated with acetylsalicylic acid, but not in rats pretreated with indomethacin or sodium salicylate. The possibility of a connection between this edema and mast cell-linked activation of kallikrein by adrenaline is discussed, as well as the possible role of acetylsalicylic acid acting as an acetylating inhibitor of these processes.Keywords
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