Red Blood Cell Life Span Using DFP32 as a Cohort Label

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Abstract
In the dog, the erythrocyte uptake of DFP32 was found to be dependent upon the dose of administered DFP32. Effective blocking of red cell uptake of isotopically-labeled DFP was achieved by prior administration of unlabeled DFP. By allowing a time interval between the administration of DFP and DFP32 the cohort of red cells synthesized in that interval could be labeled with DFP32. The cohort of erythrocytes synthesized in response to acute blood loss were so labeled and were found to have a shortened life span with a pattern of random destruction.