Physiological release of histamine-14-C in the pyramidal cat

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Abstract
Cats were chronically and acutely labeled with histidine-Cl4 and after varying periods of time, prepared for the measurement of histamine-Cl4 activity in the venous effluent from the tail or gracilis muscle. Stimulation of the sympathetic trunk, carotid sinus, or sciatic nerve all produced an increase in histamine-Cl4 when compared with control periods. Animals labeled with high concentrations of histidine-Cl4 and prepared immediately for testing indicated that histamine-C14 synthesis occurred rapidly, and that release during stimulation of the sciatic nerve was a transient phenomenon, usually peaking during the first 60 sec of stimulation. Histamine may contribute to the baroreceptor depressor reflex and possibly to other vasomotor mechanisms.