The reaction of chloro(triphenylphosphine)gold(I) with 1-methylthymine
- 1 July 1987
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 65 (7) , 1568-1575
- https://doi.org/10.1139/v87-264
Abstract
1-Methylthyminato-N3-triphenylphosphinegold(I) was prepared by reacting chloro(triphenylphosphine)gold(I) with 1-methylthymine in aqueous methanol at pH 11. The product was examined by X-ray crystallography and was found to have the orthorhombic space group C2221 (no. 20) with cell dimensions .alpha. = 12.760(7) .ANG., b = 11.530(2) .ANG., c = 31.893(5) .ANG., and 8 formula units in the unit cell. Data were collected with use of MoK.alpha. radiation and Syntex P21 diffractometer. The crystal structure was determined by standard methods and refined to R = 0.112 and Rw = 0.076 on the basis of 4760 unique reflections. Bond lengths and bond angles are normal. Packing in the crystal lattice is dominated by the triphenylphosphine rings which arrange roughly as blades of a propellor and are the source of the crystal''s chirality. The title and related compounds were also examined by 1H nmr. 13C nmr, and vibrational spectroscopy.This publication has 11 references indexed in Scilit:
- Interactions of gold coordination complexes with DNABiochemical Pharmacology, 1986
- Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexesJournal of Medicinal Chemistry, 1986
- Effects of coordinated gold compounds on in vitro and in situ DNA replicationBiochemical Pharmacology, 1985
- Metallkomplexe mit biologisch wichtigen Liganden, XXXIV. Allyl‐Palladium(II)‐ und Triphenylphosphan‐Gold(I)‐Komplexe mit Nucleobasen und NucleosidenEuropean Journal of Inorganic Chemistry, 1985
- SCREENING TRIAL WITH THE COORDINATED GOLD COMPOUND AURANOFIN USING MOUSE LYMPHOCYTIC LEUKEMIA-P3881981
- Inhibitory effects of a new oral gold compound on hela cellsCancer, 1979
- Model compounds for the interaction of silver(I) with polyuridine. Crystal structure of a 1:1 silver complex with 1-methylthymineJournal of the American Chemical Society, 1979
- EFFECT OF AURANOFIN ON DNA AND PROTEIN-SYNTHESIS IN HUMAN LYMPHOCYTES1977
- Heavy transition metal complexes of biologically important molecules. I. The crystal and molecular structure of trans-dichloro(bis(isopropyl)-sulfoxide-S)(1-methylcytosine-N)platinum(II)Canadian Journal of Chemistry, 1976
- Carbon-13 nuclear magnetic resonance spectra of uracil, thymine, and the 5-halouracilsJournal of the American Chemical Society, 1971