Sequence and expression of a novel member (LTBP‐4) of the family of latent transforming growth factor‐β binding proteins
- 14 July 1997
- journal article
- Published by Wiley in FEBS Letters
- Vol. 411 (2-3) , 164-168
- https://doi.org/10.1016/s0014-5793(97)00685-6
Abstract
Overlapping cDNA clones from human heart and melanoma libraries were used to establish the 1587‐residue sequence of a novel protein (LTBP‐4) belonging to the family of extracellular microfibrillar proteins which also bind transforming growth factor‐β. LTBP‐4 consists of 20 EG modules, 17 of them with a consensus sequence for calcium binding, 4 TB modules with 8 cysteines and several proline‐rich regions. Northern blots demonstrated a single 5 kb mRNA which is highly expressed in heart but also present in skeletal muscle, pancreas, placenta and lung. The modular structure predicts that LTBP‐4 should be a microfibrillar protein which probably also binds TGF‐β.Keywords
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