Lens Sodium and Potassium Concentrations During Galactose Induced Cataractogenesis.

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Abstract
The time course of the changes in lens Na and K was determined during cataractogenesis in weaning rats. The degree to which susceptibility to lens opacification influences the magnitude and time course of these -cation changes was studied using a relatively resistant (Carworth Farm Nelson) and two relatively susceptible (Rochester ex Wistar and Holtz-man) strains animals. Four days after initiation of galactose feeding, lens K was 60% and Na 175% of control values in animals of all three strains. In the resistant, but not susceptible strains, partial return to control values occurred at day 8. These changed concentrations were maintained from 4 to 16 days, dependent upon the degree of stain resistance to cataractogenesis. At these times, 4 to 16 days prior to actual opacification, a further decrease in K and increase in Na concentrations occurred to the values observed in mature cataracts.

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