MUMPS AND ENTEROVIRAL MENINGITIS IN TORONTO 1966

  • 1 January 1967
    • journal article
    • research article
    • Vol. 96  (20) , 1355-+
Abstract
Of 52 children admitted to hospital for apparently typical mumps meningitis in 1966, 50 had their cerebrospinal fluid (CSF) examined. In only 17 was the mumps virus isolated from the CSF. Mumps antihemagglutinin conversions or increments were detected in 32 subjects including 10 whose CSF yielded virus. Antibody conversions were found in 16 patients and 4-fold increments in another 9 whose serum pairs were collected only one to 4 days apart. Initial sera from 20 patients were obtained 3 days or less after the onset of meningitis. Antibody increments were frequently noted about one day after defervescence and clinical improvement. Interferon was detected in CSF from 2 of 8 patients, both of whom yielded virus. Enteroviruses were isolated from CSF and/or feces in 7 of 15 cases of aseptic meningitis which occurred between July and October. Six patients including 3 virus excretors showed enteroviral neutralizing antibody increments during convalescence. The dominant enteroviral serotype was coxsackie-virus A9.