Thrombomodulin Enhances the Reactivity of Thrombin with Protein C Inhibitor by Providing Both a Binding Site for the Serpin and Allosterically Modulating the Activity of Thrombin
Open Access
- 1 September 2003
- journal article
- Published by Elsevier
- Vol. 278 (39) , 37465-37470
- https://doi.org/10.1074/jbc.m307243200
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Structural requirements for the activation of human factor VIII by thrombinBlood, 2002
- The Thrombin Epitope Recognizing Thrombomodulin Is a Highly Cooperative Hot Spot in Exosite IPublished by Elsevier ,2002
- An Extensive Interaction Interface between Thrombin and Factor V Is Required for Factor V ActivationJournal of Biological Chemistry, 2001
- Protein C Inhibitor Regulates the Thrombin-Thrombomodulin Complex in the Up- and Down Regulation of TAFI ActivationThrombosis and Haemostasis, 2001
- Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin ComplexJournal of Biological Chemistry, 1995
- Purification and Characterization of TAFI, a Thrombin-activable Fibrinolysis InhibitorJournal of Biological Chemistry, 1995
- Thrombin Functions and Antithrombotic InterventionThrombosis and Haemostasis, 1995
- Regulation of blood coagulation by the protein C systemThe FASEB Journal, 1992
- Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationCell, 1991
- Inhibition and complexation of activated protein C by two major inhibitors in plasmaBlood, 1989