RESPONSE OF CITRIC ACID LEVELS TO ORAL ADMINISTRATION OF GLUCOSE. II. ABNORMALITIES OBSERVED IN THE DIABETIC AND CONVULSIVE STATE 1

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Abstract
A study of citric acid levels in response to glucose admn. was made in humans where abnormal glucose metabolism was suspected. Most diabetics show no apparent deviation from the normal citric acid level response curve on admn. of glucose orally. Certain diabetics, with neurological symptoms, show abnormalities in their citric acid response to the admn. of glucose. Some children with symptoms of convulsive seizure show abnormal citric acid response curves, with non-diabetic glucose tolerance curves. Citric acid levels can rise in pathological conditions to levels where Ca ion concn. can be significantly affected, as shown in a child with tetany with a Ca level of 8 mg.% but a citric acid level of 9.6 mg.%, which is 3-5 times the normal value.

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