INHIBITION OF MURINE LYMPHOCYTE-B PROLIFERATION BY THE NOVEL IMMUNOSUPPRESSIVE DRUG FK-506
- 1 November 1989
- journal article
- research article
- Vol. 68 (3) , 434-435
Abstract
The novel immunosuppressive drug FK-506 inhibits both cell-mediated and humoral immunity in vivo and suppresses T-lymphocyte activation at nanamolar concentrations in vitro. We report here that FK-506 also inhibits the in vitro proliferation of murine B lymphocytes induced by goat anti-mouse IgM (GaMIgM), although it does not affect the induction of proliferation by bacterial lipopolysaccharide (LPS). The action of FK-506 on B-lymphocyte proliferation thus resembles that of cyclosporin A, further strengthening the correlation between the action of the two immunosuppressive drugs previously reported for T-lymphocyte activation.This publication has 13 references indexed in Scilit:
- INHIBITION OF LYMPHOCYTE-T ACTIVATION BY THE IMMUNOSUPPRESSIVE DRUG FK-5061989
- EFFECT OF A NEW IMMUNOSUPPRESSIVE AGENT, FK506, ON HUMAN LYMPHOCYTE RESPONSES IN VITROTransplantation, 1989
- FK506Transplantation, 1988
- SPLEEN LYMPHOCYTE POPULATIONS AND EXPRESSION OF ACTIVATION MARKERS IN RATS TREATED WITH THE POTENT NEW IMMUNOSUPPRESSIVE AGENT FK-5061988
- Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.The Journal of Immunology, 1987
- The cyclosporin-A-sensitive event in lymphocyte activationAnnales de l'Institut Pasteur / Immunologie, 1987
- Cyclosporin as a probe for different modes of lymphocyte activationAnnales de l'Institut Pasteur / Immunologie, 1987
- FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.The Journal of Antibiotics, 1987
- Effects of cyclosporin A on the immune system of the mouse. I. Evidence for a direct selective effect of cyclosporin A on B cells responding to anti‐immunoglobulin antibodiesEuropean Journal of Immunology, 1982
- INHIBITION OF PROLIFERATION OF A MURINE MYELOMA CELL-LINE AND MITOGEN-STIMULATED LYMPHOCYTES-B BY THE ANTIBIOTIC AMPHOTERICIN-B (FUNGIZONE)1982