THE EFFECT OF SODIUM THIOCYANATE ON INTESTINAL SECRETION IN THE DOG

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Abstract
Na thiocyanate, given by stomach tube in a 11/2 g. dose to doga with intestinal fistulae, increases the rate of intestinal secretion. The vol. and total production of enzymes and muco-protein are affected. It appears that the results may be in accord with the reverse of Alvarez''s gradient theory[long dash]an inhibition in the stomach, a slight stimulation in the jejunum and ileum, and a still greater effect in the colon. Thiocyanate, in concs, found in the intestinal juice in these expts., had no effect on the respiration of intestinal mucosa nor on enzyme activity in vitro. Possible mechanisms of action are mentioned.

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