Microbiological transformations. Part 4. Microbiological transformations of 5α-androstan-17-ones and of 17a-aza-D-homo-5α-androstan-17-ones with the fungus Cunninghamella elegans
- 2 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 4,p. 1041-1045
- https://doi.org/10.1039/p19810001041
Abstract
The microbiological transformation of 5α-androstan-17-one, and the 3β-acetoxy- and 3α-hydroxy-derivatives, by Cunninghamella elegans is dominated by 1β,7-dihydroxylation or 7-monohydroxylation. 3α-Acetoxy-5α-androstan-17-one undergoes predominant 6β,11β-dihydroxylation. 17a-Aza-D-homo-5α-androstan-17-one and the 3α-acetoxy-derivative undergo predominant monohydroxylation at 6β or 7α, in contrast to the 3β-acetoxy-derivative which, although undergoing similar monohydroxylation, gives good yields of 9α-monohydroxylated products.This publication has 2 references indexed in Scilit:
- Microbiological transformations. Part 3. The oxidation of androstene derivatives with the fungus Cunninghamella elegansJournal of the Chemical Society, Perkin Transactions 1, 1980
- Microbiological transformations of 3α-acetoxy-17a-aza-D-homo-5α-androstan-17-one and of 3α-acetoxy-5α-androstan-17-one with the fungus Cunninghamella elegansJournal of the Chemical Society, Perkin Transactions 1, 1977