Response of the Lung to Six to 12 Hours of 100 per Cent Oxygen Inhalation in Normal Man

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Abstract
To assess the early effects of 100 per cent oxygen breathing in normal human lungs without pre-existing pulmonary disease, mechanical ventilation and blood transfusions, 11 carefully informed, healthy young men were studied. Nine breathed 100 per cent oxygen at ambient pressure for six to 12 hours, and two served as controls. To study the changes at the pulmonary vasculature level, the following determinations were made: alveolar-arterial oxygen gradient, physiologic pulmonary shunt, pulmonary artery pressure, total pulmonary resistance, cardiac output and pulmonary extravascular water volume. A comparison of the values during the equilibration period with those throughout the 100 per cent oxygen breathing period revealed no statistically significant changes.