Inhibition of SV40 gene expression by microinjected sma antisense RNA and DNA molecules
- 1 January 1991
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 19 (1) , 53-59
- https://doi.org/10.1093/nar/19.1.53
Abstract
We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis.Keywords
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