The effect of salicylate on liver glycogen in the rat

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Abstract
The effect of sodium salicylate on the liver glycogen and blood glucose of normal, adrenalectomized and adrenalectomized rats maintained on cortisone, are described. In the normal and adrenalectomized rats maintained on cortisone, a single dose of salicylate causes an initial impairment of the deposition of liver glycogen and a fall in blood glucose, but after 24 hours the levels of these substances are higher than in control animals. In adrenalectomized rats the initial effect of salicylate on liver glycogen and blood glucose is similar, but no recovery occurs after 24 hours. Some possible mechanisms to explain these effects are discussed.