Tallysomycin,a new antitumor antibiotic complex related to bleomycin IV. New biosynthetic derivatives of tallysomycin.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (6) , 658-664
- https://doi.org/10.7164/antibiotics.34.658
Abstract
A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording 2 classes of biosynthetic derivatives, with or without the .beta.-lysine moiety in the subterminal position. Of 21 derivatives prepared, tallysomycin S10b was selected for further studies in view of its favorable therapeutic indices.This publication has 10 references indexed in Scilit:
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