The suppression of oestrus in the rat during pregnancy and lactation

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Abstract
It is well known that one function of the corpus luteum is the inhibition of oestrus. This fact has been established by experiments in which corpora lutea are removed and by experiments in which the functional life of corpora is prolonged. More recently it has been shown that the corpora exercise this inhibiting influence by means of their internal secretion. The exact part they play in the suppression of oestrus during pregnancy and in lactation in the rat is, however, still obscure. An attempt was therefore made in the following investigation to study the influence of destruction of luteal tissue on the return of oestrus and on the ripening of follicles, a technique which to our knowledge has not before been applied to the rat.