Peripheral neuropathy in arsenic smelter workers

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Abstract
A double-blind controlled study of individuals exposed to arsenic trioxide in a Cu-smelting factory was conducted. Subjects fell into 3 categories of peripheral neuropathy: none, subclinical and clinical. The subclinical group had no symptoms or signs of numbness or reduced reflexes, but did have reduced nerve conduction velocity and amplitude measurements. Clinical neuropathy groups had signs and symptoms of neuropathy and electrophysiologic abnormalities. The clinical and subclinical groups correlated with increased content of arsenic in urine, hair and nails. The incidence of subclinical and clinical neuropathy was greater in arsenic workers than in unexposed controls.

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