The effect of nedocromil on weal reactions in human skin.
Open Access
- 1 October 1987
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 24 (4) , 405-408
- https://doi.org/10.1111/j.1365-2125.1987.tb03191.x
Abstract
1. Nedocromil 2% iontophoresed into human skin had no effect on wealing produced by intradermal histamine, 48/80 or house dust mite antigen. 2. Iontophoresis of 0.002‐2% nedocromil itself resulted in dose‐related wealing. 3. This wealing was reduced by 62 +/‐ 8% s.e. mean by the H1‐ receptor antagonist terfenadine which decreased histamine wealing by 68 +/‐ 2% s.e. mean. 4. Nedocromil may therefore act as a weak agonist on a skin mast cell receptor concerned with histamine release.This publication has 9 references indexed in Scilit:
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