Effects of Cromolyn on Codeine-Induced Histamine Release in Vivo
- 1 October 1984
- Vol. 39 (7) , 493-497
- https://doi.org/10.1111/j.1398-9995.1984.tb00869.x
Abstract
Cromolyn has been shown to inhibit histamine release from mast cells induced by various stimuli in vitro. However, the local effects of cromolyn on codeine-induced wheal and flare skin reactions are not well understood. Intradermal injection of codeine induced prominent whealing in almost all humans. The effect of local cromolyn injection on codeine-induced skin reactions, histamine release and ultramicroscopic changes was studied in mast cells in 10 volunteers. Injections of a 2% cromolyn solution before or together with the codeine injection does not affect the subsequent skin reactions, histamine release and ultramicroscopic changes of mast cells.Keywords
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