EFFECTS OF CHRONIC ETHANOL ADMINISTRATION ON ACYL GROUP COMPOSITION OF MITOCHONDRIAL PHOSPHOLIPIDS FROM GUINEA-PIG ADRENAL

  • 1 January 1978
    • journal article
    • research article
    • Vol. 21  (2) , 355-358
Abstract
The acyl groups of diacyl-glycerophosphocholine (GPC) and diacyl-glycerophosphoethanolamine (GPE) in guinea pig adrenals are comprised mainly of 16:0, 18:0, 18:1, 18:2 and 20:4(n-6) with only trace amounts of the longer chain polyunsaturated fatty acids. There was an increase in the proportions of 18:2 and a decrease in the 20:4(n-6) of diacyl-GPC and diacyl-GPE with respect to chronic ethanol administration. Acyl group changes were more obvious in diacyl-GPC than in diacyl-GPE. These changes might lead to an alteration of other membrane transport activities as well as functions of the adrenal gland.