The Granulation of Lactose and Starch in a Recording High-Speed Mixer, Diosna P25

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Abstract
Lactose 100 mesh was granulated faster than the 350 mesh quality. Corn starch required large volumes of granulating solution. When agglomerating pure corn starch, its loss on drying influenced the process. Suitable limits for the end-point determination when granulating a mixture of 2/3 of lactose 100 mesh and 1/3 of corn starch, with povidone as binder, were determined for the liquid addition under controlled conditions. In a 1/2 • 26 factorial experiment, the influence of the process variables on the response variables was studied. The former are the main impeller and chopper speed; the method of fluid addition; the way of adding the binder; the volume of granulating liquid added, and the wet massing time. The response variables concerned are the fraction 2.00 mm; the granule median diameter; the change in the rotation rate of the impeller shaft; and heat production in the mass. The impeller and chopper speed, the way of adding the binder, and the volume of granulating solution that was added, influenced all the response variables significantly. However, the dominating variables were the volume of solution and the impeller rate. Besides, the granule median diameter was influenced by the method of fluid addition. Also, the heat production during granulation was influenced by the method of fluid addition as well as by the wet massing time.

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