On‐line monitoring of hybridoma cell growth using a laser turbidity sensor
- 20 December 1992
- journal article
- research article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 40 (11) , 1337-1342
- https://doi.org/10.1002/bit.260401107
Abstract
A high-sensitivity turbidity probe was used for on-line monitoring of the cell concentration in batch hybridoma cultivation. Good correlation between off-line cell counts and the linearized sensor signal was found. The quality of the signal was sufficiently high to provide for on-line estimation of the specific growth rate using an efficient filtering procedure. These positive results suggest that such laser turbidity sensors will facilitate development of systems for on-line monitoring and control of animal cell cultivations. © 1992 John Wiley & Sons, Inc.Keywords
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