BIOLOGICAL ACTIONS OF 17 α-(2-METH ALL YL)-19-NORTESTOSTERONE, AN ORALLY ACTIVE PROGESTATIONAL AGENT

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Abstract
17[alpha]-(2-Methallyl)-19-nortestosterone (SC-9022) is an active progestational agent when studied in a number of biological tests. In the intrauterine assay it was estimated to be about 10 times as active as progesterone (range 5-20 times). In the subcutaneous Clauberg assay it was 25 times progesterone (12-50); in the oral Clauberg it was about 10(5-20) times the standard, progesterone administered by the subcutaneous route, and 500-2000 times orally administered progesterone. It was about 10 times as active as progesterone (a) in maintaining histamine-induced rat deciduomata, and (b) in causing increases in uterine carbonic anhydrase. SC-9022 maintained pregnancy in spayed rabbits and blocked copulation-induced ovulation in rabbits. It stimulated uterine growth in immature white mice, but antagonized the action of estrone in the same test (3-5 times progesterone). It had essentially no estrogenic effects on vaginal smears of spayed rats.