Maternal Antibodies, Childhood Infections, and Autoimmune Diseases
Top Cited Papers
- 1 November 2001
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 345 (18) , 1331-1335
- https://doi.org/10.1056/nejmra012493
Abstract
With this article by Nobel laureate Rolf Zinkernagel, the Immunology series that began in July 2000 comes to an end. Zinkernagel's thesis concerns the influence of a mother's immunologic memory on the effectiveness of childhood vaccination and the susceptibility of her child to infectious diseases. He reviews how immunity in the entire community (herd immunity) affects immune protection not only in the mother but also in succeeding generations. Zinkernagel warns that lax vaccination programs and complacency produced by improved living standards will have global effects on susceptibility to infection and autoimmune diseases.Keywords
This publication has 31 references indexed in Scilit:
- Vaccines and VaccinationNew England Journal of Medicine, 2001
- Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in miceEuropean Journal of Immunology, 1998
- Report of the Expert Panel VI Concerted efforts in the field of mucosal immunologyVaccine, 1996
- Immunological Memory and Protective Immunity: Understanding Their RelationScience, 1996
- ON IMMUNOLOGICAL MEMORYAnnual Review of Immunology, 1996
- Hepatitis B Virus ImmunopathogenesisAnnual Review of Immunology, 1995
- T-cell memory: new perspectivesImmunology Today, 1993
- Immunity to Intracellular BacteriaAnnual Review of Immunology, 1993
- Successful immunization of children with and without maternal antibody by aerosolized measles vaccine. I. Different results with undiluted human diploid cell and chick embryo fibroblast vaccinesJAMA, 1983
- MULTIPLE SERUM PROTEIN DEFICIENCIES IN CONGENITAL AND ACQUIRED AGAMMAGLOBULINEMIA 1Journal of Clinical Investigation, 1956