An Evaluation of HPLC for the Screening and Quantitation of Benzodiazepines and Acetaminophen in Post Mortem Blood*

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Abstract
High performance liquid chromatographic (HPLC) methods have been developed for the analysis of benzodiazepines, some of their metabolites and for acetaminophen in post mortem blood. The methods include a single-step extraction and the use of internal standards for quantitatlon. Two different columns, µ-Bondapack C18 and µ-Bondapak phenyl with two different mobile phases are described. The methods presented are sensitive, reproducible, relatively selective, and have been used regularly in forensic toxicological analysis.