Effects of acetazolamide and acid-base changes on biliary and pancreatic secretion

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Abstract
Effects of acetazolamide and acid-base changes on the flow and the composition of hepatic bile and pancreatic juice were studied in 24 anesthetized dogs. Acetazolamide slightly augmented the bile flow but reduced the flow response of the pancreas to secretin. Normally, there was a characteristic flow-composition relationship such that an increase in the flow was accompanied by an increase in (HCO-3) of both bile and pancreatic juice and by a fall in (Cl-) in pancreatic juice and an increase in bile (Cl-). Acetazolamide disrupted the normal flow-composition relationship in such a way that for a given flow (HCO-3) was lowered whereas (Cl-) was elevated. When plasma (HCO-3) was varied by inducing metabolic acidosis or alkalosis, it was observed that the flow and (HCO-3) in bile and pancreatic juice were proportional to plasma (HCO-3) even in the presence of acetazolamide. This apparent dependence of flow on plasma (HCO-3) was much more distinct in pancreas than in bile.