THE EFFECT OF TEMPERATURE ON THE POTENTIATION OF ADRENALIN BY THYROXINE IN THE ALBINO RAT12

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Abstract
IT WAS shown in a previous paper (1) that at 30° C, ambient temperature, thyroidectomy inhibits and injected thyroxine potentiates the calorigenic action of adrenalin, the potentiation being proportional to the daily thyroxine dose. In view of the great stimulation of metabolism by cold and the disputed role of the two hormones in this response, it seemed of interest to re-examine the interrelation between constant doses of the two hormones during short or long cold exposure. The two- to three-fold rise in metabolic rate produced by sudden exposure of animals to near-freezing temperatures has been mainly attributed to muscular activity (2, 3), supplemented by adrenalin secretion (4, 5, 6, 7, 8). On the other hand, cold adaptation, characterized by maintenance of normal rectal temperature (2, 9, 10, 11) and greater resistance to more severe cold (12, 13, 14), is largely associated with increased thyroid activity (5, 15, 16).

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