Tissue Distribution of C14-Labeled Bacterial Polysaccharide in Guinea Pig, Rat, Mouse and Rabbit.

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Abstract
Marked differences in tissue distribution of C14-labeled Klebsiella pneumoniae polysaccharide complex were found in 4 common laboratory animals. After a single intravenous injection of the C14-labeled bacterial polysaccharide the highest isotopic concentration was in the adrenal of the guinea pig, the mesenteric lymph node of the rat and the liver of the mouse. Relatively less C14 was found in the tissues of the rabbit as compared to the other 3 animal species. By simple extraction procedures approximately 30% of the C14 in liver and mesenteric lymph nodes of the rat was recovered in a polysaccharide retaining the haptenic properties of the original polysaccharide.