Estradiol Metabolism by Liver Homogenates and Microsomes of Normal and Cirrhotic Male Rats
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 11 (2) , 69-80
- https://doi.org/10.1159/000179042
Abstract
Incubation experiments show that homogenates and microsomes obtained from CCl4-induced cirrhotic livers of male rats metabolize an estradiol load at a much slower rate than preparations from normal livers. The decreased metabolic capacity results in a slower disappearance of estradiol from the incubation medium, and in a slower transformation of metabolized estradiol to polar extractable and to highly polar nonextractable metabolites.Keywords
This publication has 7 references indexed in Scilit:
- Estrogen-Androgen Imbalance in Hepatic CirrhosisAnnals of Internal Medicine, 1973
- A simplified method of sample preparation for determination of tritium, carbon-14, or sulfur-35 in blood or tissue by liquid scintillation countingAnalytical Biochemistry, 1966
- The Carbon Monoxide-binding Pigment of Liver MicrosomesJournal of Biological Chemistry, 1964
- RELATIONSHIP OF LOW PROTEIN DIET AND ASCORBIC ACID IN ESTROGEN INACTIVATION BY LIVEREndocrinology, 1958
- THE INTERCONVERSION OF ESTRONE AND ESTRADIOL-17βBY RAT LIVER SLICES1,2,3Endocrinology, 1953
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- STUDIES ON INACTIVATION OF ESTRADIOL BY THE LIVER1Endocrinology, 1943