Acute Hemolytic Anemia Associated with Infectious Mononucleosis

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Abstract
THE absence of anemia in infectious mononucleosis is generally accepted. Indeed, this fact is useful as an aid in the differential diagnosis of infectious mononucleosis and leukemia. Bernstein1 has stated that anemia of any appreciable degree does not appear in infectious mononucleosis unless associated with some complicating factor such as hemorrhage or dietary deficiency. In a study of 300 cases of infectious mononucleosis, Read and Helwig2 found only 6 cases with concomitant anemia; of these, 3 were associated with a rapidly developing leukopenia and thrombocytopenia, the anemia being a part of this pancytopenia.The occurrence of acute hemolytic anemia in . . .