Receptor‐phosphoinositidase C coupling Multiple G‐proteins?

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Abstract
Recent evidence has suggested that receptor‐mediated phosphoinositide turnover, like that of the adenylate cyclase cAMP pathway, is regulated by guanine nucleotides. It is likely that one or more guanine nucleotide‐binding proteins (G‐proteins) couple calcium‐mobilizing receptors to the activation of phosphoinositidase C. Recent studies utilizing various bacterial toxins have strongly suggested the presence of multiple G‐proteins in the regulation of receptor‐phosphoinositidase C coupling in a variety of cell types.