NON-PROGRESSIVE COURSE OF NON-A, NON-B CHRONIC HEPATITIS IN MULTITRANSFUSED HEMOPHILIACS

Google Scholar
  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (3) , 655-658
Abstract
Eleven hemophiliacs with chronic liver disease were studied prospectively for 6 yr, with liver function tests and liver biopsies carried out at intervals of 3 yr. The 2nd series of biopsies, compared with the 1st series, showed continuation of chronic persistent hepatitis in 4 patients, change to chronic lobular hepatitis in 2, and spontaneous improvement of the disease in the 4 cases who had had chronic active hapatitis characterized by moderate piecemeal necrosis. One patient with active cirrhosis died of liver failure during the follow-up period. Study of the serum and intrahepatic markers for hepatitis B and delta viruses suggests that chronic liver disease is nonprogressive in hemophiliacs who have no intrahepatic viral marker.