Pharmacological studies on prescription containing Bupleuri Radix (III)

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Abstract
Effects of a kanpo -prescription; Sairei-Toh on the antigranulomatous action of glucocorticoid were investigated using male rats. Sairei-Toh increased the activity of the antigranulomatous action of dexamethasone although treatment with only Sairei-Toh showed no significant antigranulomatous action, as compared with the controls. The granuloma formation was reduced by administration of dexamethasone 0.5 mg/kg per day and Sairei-Toh for 4 days to almost the same extent as seen with 1.5 mg/kg per day of dexamethasone. The concomitant administration of Sairei-Toh and dexamethasone slightly inhibited the increase in serum triglycerides as induced by dexamethasone but did not alter serum cholesterol levels. There was no apparent difference in body, adrenal and thymus weights between the rats treated with dexamethasone in combination with Sairei-Toh and those treated with only dexamethasone.

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