THE EFFECTS OF HYPOPHYSECTOMY ON THE RESPIRATION AND CELLULAR COMPONENTS OF THE BONE MARROW OF THE RAT1

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Abstract
Hypophysectomy in the rat results in a decrease in the percentages of neutrophilic promyelocytes and myelocytes and an increase in the concn. of lymphocytic forms in the bone marrow. The percentages of total eosinophilic cells, total nucleated erythroid elements and the erythroid-myeloid cell ratios are unaffected by hypophyseal removal. Total nucleated cell percentages (erythroid plus myeloid) are higher in bone marrow suspensions of hypophysectomized than in normal rats. The rate of O2 consumption, when based on total N concn. of the entire marrow sample, is similar in hypophysectomized and unoperated rats. When related to nucleated cell content only, the QO2(N) values for bone marrow of hypophysectomized animals are lower than those for normal rats. Alterations in the ratio of immature to more mature cellular components may provide the explanation for the change in QO2(N) observed for the nucleated cells of the marrow of hypophysectomized rats.