The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection
Top Cited Papers
- 1 October 2000
- journal article
- Published by Springer Nature in EMBO Reports
- Vol. 1 (4) , 353-358
- https://doi.org/10.1093/embo-reports/kvd073
Abstract
The Drosophila innate immune system discriminates between pathogens and responds by inducing the expression of specific antimicrobial peptide‐encoding genes through distinct signaling cascades. Fungal infection activates NF‐κB‐like transcription factors via the Toll pathway, which also regulates innate immune responses in mammals. The pathways that mediate antibacterial defenses, however, are less defined. We have isolated loss‐of‐function mutations in the caspase encoding gene dredd, which block the expression of all genes that code for peptides with antibacterial activity. These mutations also render flies highly susceptible to infection by Gram‐negative bacteria. Our results demonstrate that Dredd regulates antibacterial peptide gene expression, and we propose that Dredd, Immune Deficiency and the P105‐like rel protein Relish define a pathway that is required to resist Gram‐negative bacterial infections.Keywords
This publication has 21 references indexed in Scilit:
- Activation of the Drosophila NF‐κB factor Relish by rapid endoproteolytic cleavageEMBO Reports, 2000
- Gram-negative Bacteria-binding Protein, a Pattern Recognition Receptor for Lipopolysaccharide and β-1,3-Glucan That Mediates the Signaling for the Induction of Innate Immune Genes in Drosophila melanogaster CellsJournal of Biological Chemistry, 2000
- Signaling mechanisms in the antimicrobial host defense of DrosophilaCurrent Opinion in Microbiology, 2000
- Relish, a Central Factor in the Control of Humoral but Not Cellular Immunity in DrosophilaPublished by Elsevier ,1999
- Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappa B factorGenes & Development, 1999
- Dredd,a Novel Effector of the Apoptosis ActivatorsReaper, Grim,andHidinDrosophilaDevelopmental Biology, 1998
- Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowinJournal of Molecular Biology, 1998
- Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.Proceedings of the National Academy of Sciences, 1996
- The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila AdultsCell, 1996
- A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.Proceedings of the National Academy of Sciences, 1995