Effect of Crowding on Experimental Granuloma Formation in Mice.

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Abstract
1) Granulomas were induced subcutaneously by 5 mg pellets of cotton wet with turpentine in 90 male albino mice. Thirty-five of these mice were segregated, 55 were in groups of 5 each. Granulomas of grouped mice weighed 19% less than those of segregated mice. These results were interpreted to mean that crowding increased adrenocortical activity sufficiently to have a suppressive effect on inflammation. 2) Granulomas were induced in rats with cotton and cotton plus turpentine. Cotton plus turpentine approximately tripled the weights of the induced granulomas over those resulting from cotton alone.