Neuropathologic Outcome of Mild Cognitive Impairment Following Progression to Clinical Dementia

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Abstract
The concept of mild cognitive impairment (MCI) has become a focus for study of the evolution of Alzheimer disease (AD).1-3 Early identification of patients destined to develop AD will allow for earlier intervention in an attempt to slow or halt the progression of disease. Clinically, subtypes of MCI have been recognized, with the amnestic subtype (aMCI) having an elevated risk of progressing to clinical AD.1-4 It is unclear whether the clinical diagnosis of aMCI predicts progression to pathologic AD. Pathologic confirmation of AD in these cases is important to validate these clinical observations and to justify our use of treatments for AD in aMCI.5-8