CHANGES IN BODY COMPOSITION IN ACUTE RENAL FAILURE 1

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Abstract
Balance studies in 8 patients revealed a loss of 15% of body fat, 14% of body water, and 12% of body solids throughout oliguric and diuretic phases. Maximum negative water and electrolyte balances occurred during early diuresis which was also attended by a marked contraction of chloride space and an intracellular shift of K in exchange for Na. Optimal hydration in acute renal failure can be maintained by replacing sensible water loss plus an average of 330 ml per m2 body surface area per day. Caloric expenditure averaged 2500 calories per day. Endogenous fat constituted the main source of energy. Endogenous protein catabolism appeared to be influenced more by stress, infection, and previous nutritional status than by exogenous caloric intake.