Mucopolysaccharide Defect in Experimental Lathyrism.

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Abstract
Summary The hexosamine content of bone callus of aminoacetonitrile-treated rats has been studied 10 and 17 days after fracture and has been found to be decreased by about 50% as compared to controls. The decrease has been found to be due wholly to galactosamine, while glucosamine content remains the same. On the basis of these and of previously available data it is concluded that only Ch-4-SO4 and Ch-6-SO4 are affected by the AAN intoxication. It has also been confirmed that the solubility of collagen in the lathyritic bone callus is greatly increased.