Effect of D2O in vivo and in vitro on uptake of p-aminohippurate by rat kidney slices
- 1 November 1959
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 197 (5) , 1128-1130
- https://doi.org/10.1152/ajplegacy.1959.197.5.1128
Abstract
Kidney slices from rats in which one-third of the body water was replaced by D2O showed no impairment of the capacity to accumulate PAH, despite the moribund condition of the animals. In vitro, 100% D2O inhibited PAH uptake by 65%, oxygen consumption by only 15%, during a 1-hour incubation of kidney slices; very little PAH was taken up after the first 30 minutes.Keywords
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