Equilibration of Isoagglutinins of Human Group O Serum

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Abstract
Cross-reactive antibodies are shown to be responsible for the difference in final levels of agglutination reached after dissociation of a centrifuged group O serum-erythrocyte mixture as compared with duplicate mixtures allowed to aggregate freely. This difference is seen only with certain group O sera, it is independent of complement, and it may be eliminated by absorption of the serum with A or B erythrocytes. The phenomenon is most likely the result of steric inhibition of smaller, cross-reactive antibodies in the aggregative system.