Acetazolamide and Chlorothiazide in the Treatment of Ascites Due to Cirrhosis of the Liver

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Abstract
RETENTION of sodium and water is an important factor in the formation of ascites in cirrhosis of the liver, and the therapy of this condition usually involves measures to decrease the oral intake of sodium and to increase the urinary output by the use of diuretics. A number of patients with ascites, however, remain refractory to this program and do not respond successfully to other adjunctive measures, including the use of salt-poor albumin, potassium-containing anion-exchange resins, ACTH and corticosteroids.The introduction of newer diuretic compounds such as the carbonic anhydrase inhibitor acetazolamide§ and chlorothiazide¶ afforded further possible means for producing . . .