Evaluation of functional Analogs of CC-1065 and the Duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C2BI) alkylation subunit

This publication has 51 references indexed in Scilit:

• DNA alkylation properties of the duocarmycins: (+)-duocarmycin A, epi-(+)-duocarmycin A, ent-(−)-duocarmycin A and epi,ent-(−)-duocarmycin A
  Bioorganic & Medicinal Chemistry Letters, 1992
• Synthesis and cytotoxicity of enantiomeric pairs of duocarmycin a and its 2-epimer
  Bioorganic & Medicinal Chemistry Letters, 1992
• A potent, simple derivative of an analog of the CC-1065 alkylation subunit
  Bioorganic & Medicinal Chemistry Letters, 1991
• Synthesis and preliminary evaluation of (+)-CBI-indole2: an enhanced functional analog of (+)-CC-1065
  Bioorganic & Medicinal Chemistry Letters, 1991
• A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-convalent van der waals contacts dominant in the non-covalent CC-1065/B-DNA binding
  Chemico-Biological Interactions, 1990
• Locations of nucleosomes on the regulatory region of simian virus 40 chromatin
  Journal of Molecular Biology, 1989
• Sequence selectivity of DNA covalent modification
  Chemical Research in Toxicology, 1988
• Total synthesis of (.+-.)-N2-(phenylsulfonyl)-CPI, (.+-.)-CC-1065, (+)-CC-1065, ent-(-)-CC-1065, and the precise, functional agents (.+-.)-CPI-CDPI2, (+)-CPI-CDPI2, and (-)-CPI-CDPI2 [(.+-.)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (-)-(3bS,4aR)-deoxy-CC-1065]
  Journal of the American Chemical Society, 1988
• Total synthesis of (+)-CC-1065 and ent-(-)-CC-1065
  Journal of the American Chemical Society, 1988
• Studies on the synthesis of the antitumor agent CC-1065. Synthesis of the unprotected cyclopropapyrroloindole A portion using the 3,3'-bipyrrole strategy
  Journal of the American Chemical Society, 1987